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1.

The PD-1 expression balance between effector and regulatory T cells predicts the clinical efficacy of PD-1 blockade therapies.

Kumagai, Shogo; Togashi, Yosuke; Kamada, Takahiro; Sugiyama, Eri; Nishinakamura, Hitomi; Takeuchi, Yoshiko; Vitaly, Kochin; Itahashi, Kota; Maeda, Yuka; Matsui, Shigeyuki; Shibahara, Takuma; Yamashita, Yasuho; Irie, Takuma; Tsuge, Ayaka; Fukuoka, Shota; Kawazoe, Akihito; Udagawa, Hibiki; Kirita, Keisuke; Aokage, Keiju; Ishii, Genichiro; Kuwata, Takeshi; Nakama, Kenta; Kawazu, Masahito; Ueno, Toshihide; Yamazaki, Naoya; Goto, Koichi; Tsuboi, Masahiro; Mano, Hiroyuki; Doi, Toshihiko; Shitara, Kohei; Nishikawa, Hiroyoshi.

Nat Immunol; 21(11): 1346-1358, 2020 11.

Artículo en Inglés | MEDLINE | ID: mdl-32868929

2.

An Oncogenic Alteration Creates a Microenvironment that Promotes Tumor Progression by Conferring a Metabolic Advantage to Regulatory T Cells.

Kumagai, Shogo; Togashi, Yosuke; Sakai, Chika; Kawazoe, Akihito; Kawazu, Masahito; Ueno, Toshihide; Sato, Eiichi; Kuwata, Takeshi; Kinoshita, Takahiro; Yamamoto, Masami; Nomura, Sachiyo; Tsukamoto, Tetsuya; Mano, Hiroyuki; Shitara, Kohei; Nishikawa, Hiroyoshi.

Immunity; 53(1): 187-203.e8, 2020 07 14.

Artículo en Inglés | MEDLINE | ID: mdl-32640259

3.

Metabolic advantages of regulatory T cells dictated by cancer cells.

Kondo, Masaki; Kumagai, Shogo; Nishikawa, Hiroyoshi.

Int Immunol; 36(2): 75-86, 2024 Feb 14.

Artículo en Inglés | MEDLINE | ID: mdl-37837615

4.

Vaginal Transmission of Cancer from Mothers with Cervical Cancer to Infants.

Arakawa, Ayumu; Ichikawa, Hitoshi; Kubo, Takashi; Motoi, Noriko; Kumamoto, Tadashi; Nakajima, Miho; Yonemori, Kan; Noguchi, Emi; Sunami, Kuniko; Shiraishi, Kouya; Kakishima, Hiroki; Yoshida, Hiroshi; Hishiki, Tomoro; Kawakubo, Naonori; Kuroda, Takafumi; Kiyokawa, Takako; Yamada, Kyosuke; Yanaihara, Nozomu; Takahashi, Kazuaki; Okamoto, Aikou; Hirabayashi, Shinsuke; Hasegawa, Daisuke; Manabe, Atsushi; Ono, Kentaro; Matsuoka, Masaki; Arai, Yasuhito; Togashi, Yosuke; Shibata, Tatsuhiro; Nishikawa, Hiroyoshi; Aoki, Kazunori; Yamamoto, Noboru; Kohno, Takashi; Ogawa, Chitose.

N Engl J Med; 384(1): 42-50, 2021 01 07.

Artículo en Inglés | MEDLINE | ID: mdl-33406329

5.

Suppression from beyond the grave.

Togashi, Yosuke; Nishikawa, Hiroyoshi.

Nat Immunol; 18(12): 1285-1286, 2017 11 16.

Artículo en Inglés | MEDLINE | ID: mdl-29144496

6.

Establishment of immune suppression by cancer cells in the tumor microenvironment.

Nishikawa, Hiroyoshi.

Proc Jpn Acad Ser B Phys Biol Sci; 100(2): 114-122, 2024.

Artículo en Inglés | MEDLINE | ID: mdl-38346752

7.

The cancer epigenome: Non-cell autonomous player in tumor immunity.

Kato, Shinichiro; Maeda, Yuka; Sugiyama, Daisuke; Watanabe, Keisuke; Nishikawa, Hiroyoshi; Hinohara, Kunihiko.

Cancer Sci; 114(3): 730-740, 2023 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-36468774

8.

HLA Class I Analysis Provides Insight Into the Genetic and Epigenetic Background of Immune Evasion in Colorectal Cancer With High Microsatellite Instability.

Kawazu, Masahito; Ueno, Toshihide; Saeki, Koichi; Sax, Nicolas; Togashi, Yosuke; Kanaseki, Takayuki; Chida, Keigo; Kishigami, Fumishi; Sato, Kazuhito; Kojima, Shinya; Otsuka, Masafumi; Kawazoe, Akihito; Nishinakamura, Hitomi; Yuka, Maeda; Yamamoto, Yoko; Yamashita, Kazuo; Inoue, Satoshi; Tanegashima, Tokiyoshi; Matsubara, Daisuke; Tane, Kenta; Tanaka, Yosuke; Iinuma, Hisae; Hashiguchi, Yojiro; Hazama, Shoichi; Khor, Seik-Soon; Tokunaga, Katsushi; Tsuboi, Masahiro; Niki, Toshiro; Eto, Masatoshi; Shitara, Kohei; Torigoe, Toshihiko; Ishihara, Soichiro; Aburatani, Hiroyuki; Haeno, Hiroshi; Nishikawa, Hiroyoshi; Mano, Hiroyuki.

Gastroenterology; 162(3): 799-812, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-34687740

9.

Regulatory T-cell development in the tumor microenvironment.

Itahashi, Kota; Irie, Takuma; Nishikawa, Hiroyoshi.

Eur J Immunol; 52(8): 1216-1227, 2022 08.

Artículo en Inglés | MEDLINE | ID: mdl-35879813

10.

Significance of regulatory T cells in cancer immunology and immunotherapy.

Sugiyama, Daisuke; Hinohara, Kunihiko; Nishikawa, Hiroyoshi.

Exp Dermatol; 32(3): 256-263, 2023 03.

Artículo en Inglés | MEDLINE | ID: mdl-36458459

11.

Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation.

Matsumoto, Masanori; Baba, Akemi; Yokota, Takafumi; Nishikawa, Hiroyoshi; Ohkawa, Yasuyuki; Kayama, Hisako; Kallies, Axel; Nutt, Stephen L; Sakaguchi, Shimon; Takeda, Kiyoshi; Kurosaki, Tomohiro; Baba, Yoshihiro.

Immunity; 41(6): 1040-51, 2014 Dec 18.

Artículo en Inglés | MEDLINE | ID: mdl-25484301

12.

Complete response to definitive chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma.

Habu, Takumi; Kumanishi, Ryosuke; Ogata, Takatsugu; Fujisawa, Takeshi; Mishima, Saori; Kotani, Daisuke; Kadowaki, Shigenori; Nakamura, Masaki; Hojo, Hidehiro; Fujiwara, Hisashi; Kumagai, Shogo; Koyama, Shohei; Fujita, Takeo; Kinoshita, Takahiro; Nishikawa, Hiroyoshi; Yano, Tomonori; Tajika, Masahiro; Muro, Kei; Mitsunaga, Shuichi; Kojima, Takashi; Bando, Hideaki.

Esophagus; 20(3): 533-540, 2023 07.

Artículo en Inglés | MEDLINE | ID: mdl-36750480

13.

CYBERTRACK2.0: zero-inflated model-based cell clustering and population tracking method for longitudinal mass cytometry data.

Minoura, Kodai; Abe, Ko; Maeda, Yuka; Nishikawa, Hiroyoshi; Shimamura, Teppei.

Bioinformatics; 37(11): 1632-1634, 2021 07 12.

Artículo en Inglés | MEDLINE | ID: mdl-33051653

14.

Genomic determinants impacting the clinical outcome of mogamulizumab treatment for adult T-cell leukemia/lymphoma.

Tanaka, Norio; Mori, Seiichi; Kiyotani, Kazuma; Ota, Yuki; Gotoh, Osamu; Kusumoto, Shigeru; Nakano, Nobuaki; Suehiro, Youko; Ito, Asahi; Choi, Ilseung; Ohtsuka, Eiichi; Hidaka, Michihiro; Nosaka, Kisato; Yoshimitsu, Makoto; Imaizumi, Yoshitaka; Iida, Shinsuke; Utsunomiya, Atae; Noda, Tetsuo; Nishikawa, Hiroyoshi; Ueda, Ryuzo; Ishida, Takashi.

Haematologica; 107(10): 2418-2431, 2022 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-35417939

15.

Engineering strategies for broad application of TCR-T- and CAR-T-cell therapies.

Watanabe, Keisuke; Nishikawa, Hiroyoshi.

Int Immunol; 33(11): 551-562, 2021 10 29.

Artículo en Inglés | MEDLINE | ID: mdl-34374779

16.

Newly emerged immunogenic neoantigens in established tumors enable hosts to regain immunosurveillance in a T-cell-dependent manner.

Muramatsu, Tomoaki; Noguchi, Takuro; Sugiyama, Daisuke; Kanada, Yoshie; Fujimaki, Kaori; Ito, Sachiko; Gotoh, Momokazu; Nishikawa, Hiroyoshi.

Int Immunol; 33(1): 39-48, 2021 01 01.

Artículo en Inglés | MEDLINE | ID: mdl-32729901

17.

Novel anti-GARP antibody DS-1055a augments anti-tumor immunity by depleting highly suppressive GARP+ regulatory T cells.

Satoh, Kazuki; Kobayashi, Yoichi; Fujimaki, Kaori; Hayashi, Shinko; Ishida, Saori; Sugiyama, Daisuke; Sato, Takahiko; Lim, Kyungtaek; Miyamoto, Megumi; Kozuma, Shiho; Kadokura, Michinori; Wakita, Kenichi; Hata, Masato; Hirahara, Kazuki; Amano, Masato; Watanabe, Ichiro; Okamoto, Atsushi; Tuettenberg, Andrea; Jonuleit, Helmut; Tanemura, Atsushi; Maruyama, Shoichi; Agatsuma, Toshinori; Wada, Teiji; Nishikawa, Hiroyoshi.

Int Immunol; 33(8): 435-446, 2021 07 23.

Artículo en Inglés | MEDLINE | ID: mdl-34235533

18.

A multicenter, open-label, single-arm phase I trial of neoadjuvant nivolumab monotherapy for resectable gastric cancer.

Hasegawa, Hirotaka; Shitara, Kohei; Takiguchi, Shuji; Takiguchi, Noriaki; Ito, Seiji; Kochi, Mitsugu; Horinouchi, Hidehito; Kinoshita, Takahiro; Yoshikawa, Takaki; Muro, Kei; Nishikawa, Hiroyoshi; Suna, Hideaki; Kodera, Yasuhiro.

Gastric Cancer; 25(3): 619-628, 2022 05.

Artículo en Inglés | MEDLINE | ID: mdl-35254550

19.

Study protocol for JCOG1807C (DEEP OCEAN): a interventional prospective trial to evaluate the efficacy and safety of durvalumab before and after operation or durvalumab as maintenance therapy after chemoradiotherapy against superior sulcus non-small cell lung cancer.

Aokage, Keiju; Tsuboi, Masahiro; Zenke, Yoshitaka; Horinouchi, Hidehito; Nakamura, Naoki; Ishikura, Satoshi; Nishikawa, Hiroyoshi; Kumagai, Shogo; Koyama, Shohei; Kanato, Keisuke; Kataoka, Tomoko; Wakabayashi, Masashi; Fukutani, Miki; Fukuda, Haruhiko; Ohe, Yuichiro; Watanabe, Shun-Ichi.

Jpn J Clin Oncol; 52(4): 383-387, 2022 Apr 06.

Artículo en Inglés | MEDLINE | ID: mdl-34999817

20.

PD-1⁺ regulatory T cells amplified by PD-1 blockade promote hyperprogression of cancer.

Kamada, Takahiro; Togashi, Yosuke; Tay, Christopher; Ha, Danbee; Sasaki, Akinori; Nakamura, Yoshiaki; Sato, Eiichi; Fukuoka, Shota; Tada, Yasuko; Tanaka, Atsushi; Morikawa, Hiromasa; Kawazoe, Akihito; Kinoshita, Takahiro; Shitara, Kohei; Sakaguchi, Shimon; Nishikawa, Hiroyoshi.

Proc Natl Acad Sci U S A; 116(20): 9999-10008, 2019 05 14.

Artículo en Inglés | MEDLINE | ID: mdl-31028147

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